The fire burning in Boulder County sparked worries of a hazmat emergency as flames were said to be approaching a property with liquid nitrogen tanks.
The fire torched hundreds of homes and businesses on Thursday, sparking massive evacuations as first responders continue to help people escape the blaze.
On Thursday afternoon, fire crews were said to be working to evacuate a Capella Space building in Louisville, a maker of radar imagery products.
"Caller says there are 2-4 tanks of liquid nitrogen that could explode if they catch fire," one Twitter user wrote.
Others said they heard the same on a fire rescue scanner, with one person offering their best wishes for the business.
"Let your Colorado space community know if there's anything we can do for you all," the Twitter user wrote.
Capella Space and fire rescue could not immediately be reached for comment.
The concerns came as the wildfire reportedly surrounded a Tesla store with a photo showing fire on the side of the building and smoke filling the area.
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The US Sun contacted Tesla for more information about the store.
Up to 32,000 people living in the towns of Superior and Louisville were evacuated as the blaze, dubbed the Marshall Fire, spread to 1,600 acres.
No deaths have been reported so far, though first responders said an officer was among at least six people who were hurt.
Colorado Governor Jared Polis said a fire this large near a population center was "absolutely devastating."
The flames came dangerously close to Avista Adventist Hospital in Louisville, where management was forced to evacuate the entire hospital, including intensive care, neonatal intensive care, and emergency department patients.
Good Samaritan Hospital in Lafayette was evacuating its most critical patients as the fire raged into the night, CBS Denver reported.
One Twitter user took to social media to share a fiery scene and explained: "Twenty minutes ago, this house along Harper Lake in Louisville was untouched by fire.
"Now it’s gone. Two people stand outside."
As the fires spread, Tesla Owners Club of New Mexico tweeted: "Thinking good thoughts for all our friends and everyone up north in Colorado.
"Including the Tesla employees and customers impacted by the fires."
Colorado inside linebackers coach Mark Smith revealed his family "lost everything" from the fires.
He tweeted: "Just got word that every material possession we had today is now gone.
"Our home, cars, and everything we had in our home lost to the fires that ripped through our community. Thank you to those who reached out.
"Processing how to completely start over and grateful for our health."
The Boulder Office of Emergency Management took to Twitter around 9.30pm local time to urge people not to call the Call Center if their county isn't in danger.
"If you live outside of Boulder County you are NOT in any danger at this time. Please do not call the Call Center at this time," the management team tweeted.
"Call takers are overwhelmed and there is no danger to other counties at this time. As always, stay alert to your surroundings."
According to The Colorado Sun, at least 600 homes and businesses in neighborhoods Superior and Louisville east of Boulder burned on Thursday.
The fire quickly spread as wind gusts reached 110mph.
As of 9.50pm MST, at least six people were injured and treated for burns.
Speaking at a press conference, Boulder County Sheriff Joe Pelle said: "This was consuming football-field lengths of land in seconds.
"We had never seen anything like it. This was a horrific event."
And although no fatalities or missing persons were reported at the time, Pelle added: "But given the ferocity and scope of this fire, it would not surprise me if we find casualties."
Broomfield Police shared shocking footage to Twitter of houses burning as police drive past.
"This video was taken by BPD Patrol Officers in Superior…E of US-36…this afternoon," the tweet read.
"Our thoughts are with our neighbors tonight who lost their homes and businesses. We continue to assist our law enforcement and fire partners as necessary.
'Truly historic windstorm'
Earlier on Thursday, Boulder's National Weather Service said: "We are in the midst of a truly historic windstorm across the front range, foothills, and urban corridor," The News Caravan reported.
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