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Syracuse at Louisville odds, picks and best bets

The Syracuse Orange (4-6) will take on the Louisville Cardinals (6-4) in an ACC matchup Saturday of Week 13 with a 4 p.m. ET kickoff. Below, we analyze the Syracuse-Lousiville odds and betting lines, while providing college football betting tips and advice on this matchup.

Syracuse vs. Louisville: Three things you need to know

1. Syracuse has lost 13 of its last 18 games on the road, including three of the previous four this season.

2. Louisville has covered the spread in just seven of its last 20 games.

3. The Over hit in 12 of the last 18 games involving the Cardinals.


Get some action on this game or others by placing a bet at BetMGM!


Syracuse vs. Louisville: Odds, betting lines and picks

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated at 5 p.m. ET.

Prediction

Lousiville 35, Syracuse 24

Moneyline (ML)

LOUISVILLE (-345) opens this contest as a big home favorite in the inter-conference matchup with Syracuse (+270). Given Syracuse’s struggles away from home, it would be quite surprising if it were able to win outright. Expect Lousiville to win at home in what could be a sloppy ACC game.

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Against the Spread (ATS)

LOUISVILLE (-9.5, -115) opens this contest as a two-score favorite. Along with the 6-4 record on the season, Lousiville has covered the spread in six of its 10 games, while Syracuse has covered in just three of its 10 games. Expect this one to come down to the wire, but for Lousiville to ultimately win by double-digits.

Over/Under (O/U)

The total is set at 62.5. Both sides are allowing more than 28 points per contest and have been destroyed by better competition. However, neither offense is all that exciting, which could lead to the UNDER (-110).

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