Emergency services rushed to the scene after a person fell from London Bridge, police say.
City of London Police tweeted: "Upper Thames Street is currently closed west bound near Fish Street Hill due to an ongoing incident involving a person who has fallen from London Bridge."
They advised people to find alternative routes where possible.
Some transport services are being diverted amid the incident.
TfL Bus Alerts tweeted: "Route 344 is diverted due to a police incident which has caused Lower Thames Street to be closed westbound near London Bridge.
"Services are diverted via London Bridge, Southwark Street and Southwark Bridge Road."
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